43. DOC for herpes zoster ? Valaciclovir
44. MOA of penicillin ? Inhibit cell wall synthesis
45. DOC for chylamydia trachomatis ? Azithromycin
46. Anti-TB causing gout ? Pyrazinamide
47. Anti-TB combination safer in patient who develops hepatitis while on ATT ? Ethambutol and streptomycin
48. Mechanism by which Acetazolamide lowers intraocular pressure ? Reduced aqueous formation
49. Antidote for dicoumarol poisoning ? Vitamin K
50. Dose of warfarin is managed by ? INR
51. Breast cancer chemotherapeutic agent which may cause osteoporosis ? Letrozole
52. Longest acting beta adrenergic blocker ? Nadolol
53. Treatment of severe cystic acne ? Isotretinoin
54. Drug of choice for trachoma which can be administered as once a day dosing ? Azithromycin
55. Drug contraindicated in glaucoma patient suffering from bronchial asthma ? Timolol
56. First line chemotherapeutic agent for cancer cervix ? Cisplatin
57. Drug of choice for dermatitis herpetiformis ? Dapsone
58. Drug of choice for paroxysmal supraventricular tachycardia ? Adenosine
59. NPH is which type of insulin ? Intermediate acting
60. Oral agent for treating scabies ? Ivermectin
61. Route of administration of vitamin B12 in severe Megaloblastic anemia ? I/ M
62. DOC for filariasis ?
1. DEC
2. Ivermectin
63. Disulfiram acts by competitive inhibition of which enzyme ? Aldehyde dehydrogenase
64. Sildenafil acts by blocking which enzyme ? Phospho-di-esterase 5
65. Aspirin acts by inhibiting the production of ? Thromboxane
66. Insulin lispro is acting insulin ? Rapid
67. DOC for tetanus ? Doxycycline
68. DOC for meningitis due to listeria ? Ampicillin
69. Cyclophosphamide belongs to which group ? Alkylating agent
70. DOC for CML ? Imatinib mesylate
71. MOA of aspirin ? Inhibits thromboxane A2 formation
72. Dose of INH in infants ? 5 mg/ kg orally QID
73. Which hormone controls prolactinemia ? Dopamine
74. Protein which prevents absorption of biotin ? Avidin
75. MOA of methotrexate ? Inhibits dihydrofolate reductase
76. DOC for ADHD ? Methylphenidate
77. Which drug causes grey baby syndrome ? Chloramphenico
78. Reverse transcriptase inhibitors are used for managing which infection ? HIV
79. Which antihypertensive agent is contraindicated in pregnancy ? ACE inhibitors
80. Mechanism of action of ethanol in methyl alcohol poisoning is by competitively inhibiting which enzyme ? Alcohol dehydrogenase
81. Enzyme needed for conversion of norepinephrine to epinephrine ? Phenyl-ethanol-amine-N-methyl-transferase
82. Drug of choice for scabies ? Permethrin
83. Antipsychotic drug having LEAST extrapyramidal symptoms ? Clozapine
84. Mechanism of action of fusion inhibitor drug ? CCR5 inhibitor
85. Nevirapine belongs to ? NNRTI
86. DOC for gonorrhoea ? Ceftriaxone
87. Highly ionized drugs are mainly excreted by ? Kidneys
88. Hemolytic uremic syndrome can be a side effect of which anticancer drug ? Mitomycin
89. Drug used to treat akathisia ? Propranolol
90. Most emetogenic anticancer drug ? Cisplatin
91. Most widely used anticancer drug ? Cisplatin
92. Most common side effect of inhaled beclomethasone dipropionate ? Oropharyngeal candidiasis
93. NRTI having maximum tendency to cause peripheral neuropathy ? Stavudine
94. Management of choice for scorpion bite ? Anti-venin
95. Best way to manage a patient presenting with aspirin poisoning ? Make urine alkaline with NaHC03
96. Mechanism of action of statins? Inhibition of HMG CoA reducatse
97. Oral hypoglycemic agent of choice in obese patients ? Metformin
98. Define pharmacovigilance ? Monitoring adverse effects of drugs
99. 100% bioavailability is seen with which route of administration ? Intravenous
100. Longest acting neuromuscular blocking agent ? Doxacuronium (90-120 minutes)
101. Drug used in primary gout ? Colchicines, NSAID *
102. Mechanism of action of botulinum toxin ? Presynaptic inhibition of release of acetylcholine
103. Drugs used in Alzheimers disease ? Rivastigmine, Donepezil
104. Mechanism of action of diazepam ? GABA facilitator'
105. Mechanism of action of digitalis ?
106. Define bioavailability ? After oral administration, the fraction of drug reaching the systemic circulation in unchanged form
107. Mechanism of action of cyclosporine ? Inhibits interleukin-2
108. Which ATT is microsomal inducer drug ? Rifampin
109. Site of action of thiazide diuretics ? Distal convoluted tubules
110. Sildenafil, a PDE-5 inhibitor is used for ? Erectile dysfunction
111. Urinary retention is rare with ipratropium bromide because ? Poor absorption from lungs and GIT
112. Bioavailability by intravenous route ? 100%
113. Which drug acts by decreasing phospho-di-esterae IV/ PDE-4 activity: ? Aminophylline
114. Bizarre effect of drugs is included in which class of adverse effects of drugs ? Class B
115. For massive reduction in filariasis, which drug is given along with DEC ? Albendazole
116. Which anti-malarial is contraindicated in pregnancy ? Primaquine
117. Heparin toxicity is assesed by ? aPTT
118. Mechanism of action of botulinum toxin ? Inhibition of release of acetylcholine at neuromuscular junction
119. ATT which can be given in renal failure ? INH
120. Drug of choice for hyperthyroidism in pregnancy ? Propylthiouracil
121. What is the common side-effects of giving intrathecal opioid ? Itching
122. Use of nilotinib ? Preferred drug for Imatinib resistant CML
1. Commonest circumstance of Hanging? suicide
2. In judicial hanging, fracture and dislocation of vertebra involves? Commonly C3 and C4, rarely C2 and C3
3. Sure sign of ante mortem hanging is? Dribbling of saliva at the angle of mouth
4. LYNCHING is a form of? Homicidal hanging
5. MUGGING is strangulation by compressing throat with? Foot, knee or bend of elbow etc.
6. BANSDOLA is a form of asphyxial death in which? Bamboo or lathi is used to compress the throat of victim to death.
7. SIX PENNY BRUISES? Bruises found in neck due to finger tips in throttling
8. Overlying is a form of death in children due to? Accidental smothering by their mothers
9. Ligature force require to block the? Jugular veins – 2 kg Carotid artery – 3.5 kg Trachea – 15 kg Cerebral arteries /Vertebral arteries 16.6 to30 Kg
10. In partial hanging the pressure required to occlude the blood vessels of neck, carotid arteries? 3.5 kg
11. Mode of death in drowning in fresh water? Haemodilution, ventricular fibrillation circulatory overload
12. Amount of reduced Hb required clinically to develop cyanosis? 5gnm%
13. Mode of death due to drowning in salt water? Pulmonary oedema
14. Death occurs early in? Fresh water drowning, due to haemodilution, haemolysis and increased levels of potassium, with resultant circulatory overload with cardiac arrhythmia.(Ventricular fibrillation
15. Fatal period in typical drowning? 5 minutes
16. Secondary drowning refers to deaths after? 20 minutes to 4 days of drowning (due to ARDS)
17. Diagnostic sign of drowning is? Fine white leathery tenacious froth at mouth and nostrils
18. Washerwoman’s skin is found in? Drowning (antemortem)
19. Paltauf’s haemorrhages are found in? Drowning
20. Most reliable proof of drowning is? Diatoms test
21. Diatoms in drowning are found in? Brain, Liver, Bone Marrow
22. Emphysema aqueosum is seen in? Drowning (antemortem)
23. Commonest cause of death in SCUBA diving? Drowning
24. Aseptic bone necrosis in SCUBA diving occurs in? Neck of femur Humerus Upper end of tibia
25. The atmospheric pressure increases by 1 atm. For? Every 10 meters increase in underwater depth
26. Nitrogen narcosis can occur at a depth of? 30 metres of seawater
27. Pulmonary barotrauma occurs during? Rapid ascent
28. Healing by first intention is completed by? 7 day
29. Healing by first intention on the face occurs within? 3 – 5 days
30. WBCs in a gaping wound are found within? 12 hours
31. Haematoma in a fracture is formed by? 1st – 3rd day
32. The scar of a wound becomes tough within? 6months
33. Fibrous scar in wound is formed in? 3 – 4 weeks34. The bone ends in fracture glue together in? One week
34. Ossification in a callus starts by? 14th day
35. Primary callus formation at a fracture site occurs by? 3rd – 14th day
36. If a tooth is knocked out, the socket cavity fills up within? 7 – 10 days
37. Bleeding after knocking a tooth out usually stops within? 24 hours
38. Calcium deposition in fracture of skull occurs in? 14days
39. Commonest site for contusion and laceration of brain? Under surface of frontal lobe, tips of temporal or frontal lobes
40. Commonest site for? Upper and subdural haemorrhage posterior aspect of cerebral hemisphere
41. Commonest cause of subdural haemorrhage? Rupture of duralvenous sinuses
42. Contre coup injuries are a result of? Shearing stresses in the brain
43. Stunning is type of? Concussion of the brain (concussion cerebri)
44. Retrograde amnesia is a feature of? Concussion of the brain
45. Extradural haemorrhages are commonly caused by rupture of? Middle meningeal artery of the sylvian point
46. Extradural haemorrhages are associated with fracture of? Temporal orparietal area
47. Rupture of spleen is usual at? Concave or inner surface
48. Full thickness skin is lost in case of scald injuries with temperature of water? > C?70
49. Wart like growths in finger nails is caused by? Burns from X-rays
50. Infra red rays cause? Necrosis and toughening of involved tissue
51. Red line of demarcation is absent in? Burns due to chemicals, Electrocution
52. Burns that disappear after death? First degree (Dupuytren’s)
53. Fatal sites of burn injury Genital organs, Head Face, Lower abdomen
54. Delayed deaths due to burns occur within? First week
55. Pugilistic attitude occurs due to? Coagulation of albumin
56. Curling's ulcers in burn patients are found in? First part of the duodenum
57. Vesicles in postmortem burns contain? air
58. Drugs producing schizophrenia like syndrome are? d-LSD
59. Gjessing’s variety of catatonia occurs due to disturbance of? Nitrogen metabolism
60. Commonest type of psychosis in chronic alcoholism is? Delirium tremens
61. Epilepsy associated with automatism? Psychomotor epilepsy
62. Holograph Will? Written by the testator in his own handwriting
63. Maximum period of detention in case of insane person with permission of magistrate? 30 days
64. Most common illness giving rise to murder or suicide? Depression
65. Illegal detention of lunatics is punished under? Section – 93 of Indian Lunacy Act
66. Testamentary capacity means that the mental capacity to make a valid will? He must be major, must be of sound disposing mind
67. Pyromania? An impulse to set valuable things on fire
68. Kleptomania? An irresistible desire to steal articles of little or no value
69. Mutilomania? Irresistible desire to hurt or torture animals (especially pets)
70. Dipsomania? Inability to stay off alcohol
71. Trichotillomania? Irresistible urge to pull out one’s own hair
72. Indian lunacy act? 1912
73. The Mental Health Act 1987 came into effect is? April, 1993
74. Usual sites of rupture in stomach due to trauma is at? Pyloric end, greater curvature of stomach
75. Blow on epigastric region causes sudden death by? Reflex action through solar plexus
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