One Liner (26/05/2019)
Published on May 26, 2019, 2:11 p.m.

1. Adult worm in lymphatic filariasis resides in ? Lymphatics

2. Microfilariae in lymphatic filariasis resides in ? Blood

3. Schuffner dot’s are seen in ? Plasmodium vivax

4. Dot’s seen in Plasmodium falciparum ? Maurer dots

5. Stage of falciparum NOT seen in peripheral blood smear ? Schizont

6. Giardia lamblia infestation can lead to ? Malabsorption

7. Infective form of malarial parasite ? Sporozoites

8. Highly specific and sensitive test for diagnosing Kala-azar ? Immunoflourescent antibody test

9. LD bodies are associated with ?  Kala-azar

10. MC parasitic infestations in HIV ? Cryptosporodium, Strongyloides

11. Cyclops is a part of life cycle of ? Dracunculiasis

12. Kala-azar is transmitted by ? Sandfly

13. Diphyllobothrum latum causes ? Megaloblastic anemia

14. Q fever is caused by ? Coxiella burnetti

15. Babesiosis is MC transmitted by ? Ticks

16. Most virulent plasmodium species ? Falciparum

17. CLM/Cutaneous larva migrans is associated with ? Ancylostoma brazileinse

18. VLM/Visceral larva migrans is associated with  ? Toxocara

19. Visceral leishmaniasis is caused by ? L. donovani

20. Cutaneous leishmaniasis is caused by ? L. tropica

21. DOC for Kala-azar ? Sodium stibgluconate

22. Oral drug for Kala-azar ? Miltefosine

23. Prmastigote form of Leishmania is found in ? GIT of sandfly

24. Sabin Feldman dye test is done for diagnosing ? Toxoplasmma

25. Crescentic macrogametocyte are associated with plasmodium ? Falciparum

26. Definitive host in echinococcoisis ? Dog

27. Napier’s aldehyde test is done for ? Leishmaniasis

28. Cysticercosis is caused by ? Taenia solium

1. Treatment of Zoliinger Ellison syndrome ? Proton pump inhibitors

2. Baclofen is used in ? Spasticity

3. Flumazenil is an antidote for ? Benzodiazepines

4. Dopamine is preferred over dobutamine in treatment of renal shock because of ? Renal vasodilatory effects

5. Therapeutic index of a drug signifies ? Safety

6. Optimal effect is exerted over a narrow range by a drug, i his is known as ? Therapeutic window phenomenon

7. If a constant AMOUNT of drug is excreted, it is known as ? Zero order reaction

8. Drugs causing pulmonary fibrosis ? Buslphan

9. Shortest acting beta blocker ? Esmolol

10. 5HT3 antagonist ? Ondansetron

11. Drug used in acetaminophen toxicity ? N-acetyl cysteine

12. 2 Side effects of spironolactone ? Gyanecomastia, Hyperkalemia

13. DOC for diabetes insipidus ? Demeclocycline

14. Feared complication of metformin ? Lactic acidosis

15. Oral hypoglycaemic agent causing cholestatic jaundice ? Chlorpropamide

16. Effect of insulin on potassium ? Intracellular entry

17. Nevirapine belongs to ? NNRTI

18. Enzyme inhibited by theophylline ? Phospho-di-esterase 4

19. 2 factors which decrease theophylline levels? Smoking, Microsomal enzyme inducer drugs

(rifampin)

20. Side effect of parenteral steroids ? Posterior subcapsular cataract

21. MOA of sulfonamides and trimethoprim ? Inhibits Dihydro Folate Reductase enzyme

22. DOC for MRSA infection ? Vancomycin

23. DOC for pseudomembranous colitis ? Metronidazole

24. DOC for toxoplasmosis and pneumocytis carinii ? Co-trimoxazole

25. Chemoprophylactic agent for rheumatic fever ? Benzathine penicillin

26. DOC for malaria in pregnancy ? Chloroquine

27. DOC for NSAID induced ulcer ? Proton pump inhibitors

28. Anti TB causing retrobulbar neuritis ? Ethambutol

29. Most rapidly acting drug against M. leprae ? Rifampin

30. Anti hypertensive absolutely contraindicated in pregnancy ? ACE inhibitors

31. MOA of allopurinol ? inhibits Xanthine Oxidase

32. Orally taken drug for scabies ? Ivermectin

33. Drugs which lowers lipid levels by inhibiting HMG-CoA reductase enzyme ? Statins

34. Mast cell stabilizer drug is ? Cromolyn sodium

35. Antihypertensive agent of choice in pregnant lady ? Methyi-dopa

36. Drug indicated for hyperthyroidism during pregnancy ? Propyl Thiouracil

37. Hemorrhagic cystitis is a complication of ? Cyclophoshphamide

38. To treat methotrexate toxicity, which drug is used ? Folinic acid

39. Retroperitoneal fibrosis is caused by ? Methysergide

40. Monitoring tool for low molecular weight heparin ? Anti Factor Xa

41. Anti-TB drug safer in liver disease ? Ethambutol and streptomycin

42. DOC for cerebral malaria ? Quinine

1.    Celsus first listed the 4 cardinal signs ofinflammation? Rubor, tumor, calor&dolor

2.    Virchow added 5th sign? Functiolaesa

3.    Earliest feature? Alteration in microvasculature

4.    Vascular response irrespective of injury? Transient arteriolar vasoconstriction followed bypersistent progressive vasodilation

5.    Inflammation? • Visible response to immune reaction• Protective response

6.    First microscopic description of inflammation wasgiven by? Julius Cohnheim

7.    The most common mechanism of vascular leakageis by formation of endothelial gaps in venules? Due to contraction of endothelial cells

8.    Increased O2 consumption by activatedphagocytic WBC? Respiratory burst

9.    Transmigration across the endothelium is alsocalled as? Diapedesis

10.    Virtual lining of endothelium by White cells iscalled? Pavementing

11.    ?-selectin binds to glycoproteins? Glycam -1 and CD 34

12.    P-selectin is present in membrane of specificintracytoplasmic endothelial granules? Weibel Palade bodies(VWF is also present)

13.    Neutrophils at the site of inflammation are foundwithin? First 6-24 hrs

14.    Monocytes predominate at site of inflammation in? 24-48 hrs

15.    Chemotactic agents bind to? G-protein coupled receptors (GPCRs) on surface ofleucocytes

16.    Commonest morphological type of pancreatitis? Chronic calcifying pancreatitis

17.    Commonest cause of chronic pancreatitis? Alcoholism

18.    Protein which prevents intraluminal precipitation of calcium carbonate and deficiency of which predisposes to chronic pancreatitis? Lithostatine

19.    Commonest site of origin of carcinoma pancreas? Duct epithelium

20.    Commonest site of carcinoma pancreas? Head of pancreas (70%)

21.    Commonest cancer associated with migratorythrombophlebitis? Carcinoma pancreas

22.    Commonest islet cell tumour is? Beta cell tumour (Insulinoma)

23.    Commonest site of gastrinoma other sites? PancreasDuodenum, Peripancreatic region

24.    The type of pancreatic tumour associated with gallstones? Delta cell tumour

25.    Diabetic microangiopathy is most evident in?  Retina

26.    Most severely damaged organ in diabetes? Kidney

27.    Commonest lesion found in diabetic neuropathy? Symmetric peripheral neuropathy

28.    Most important cause of diabetic neuropathy andretinopathy? Accumulation of sorbitol

29.    Most important cause of diabetic micro andmicroangiopathy? Advanced Glycosylation End products (AGE)

30.    Gasrin is a biochemical marker for? Pancreatic neuroendocrine tumor

31.    More than 50% of gastrin producing tumors? Are locally invasive or have already metastasizedat the time of diagnosis.

32.    Type of tumor associated with migratory,necrotising skin erythema and anaemia? ? - cell tumor (glucagonomas)

33.    Pseudomyxomaperitonei is associated with? (1) Mucinous cystadenocarcinoma of appendix (2) Mucinous cystadenocarcinoma of ovary (3) Pancreatic mucinous malignant tumors

34.    Commonest cause of sterile peritonitis? Bile

35.    Commonest cause of bacterial peritonitis? Appendicitis

36.    Infiltration of epidermis by inflammatory cells isknown as? Exocytosis

37.    Hyperplasia of stratum spinosum is referred to as? Acanthosis

38.    Abnormal keratinization occurring prematurely incells below stratum granulosum is known as? Dyskeratosis

39.    Linear pattern of melanocyte proliferation withinthe epidermal basal layers referred as? Lentiginous hyperplasia

40.    Red pink nodular nevus that may be confusedwith hemangioma clinically? Spitz nevus

41.    Decapitation secretion? Apocrine glands

42.    Goose skin? Contraction of arrectorpilli muscle

43.    Most common childhood pigmented lesion? Freckle (epulis)

44.    Lentigo? Benign hyperplasia of melanocytes,Do not darken when exposed to light

45.    Commonest cutaneous lesions? Fibroepithelial polyps (acrochordons)

46.    Miliaria crystalline? Obstruction of sweat duct within stratum corneum

47.    Miliariarubra? Obstruction of sweat duct deep within epidermis

48.    Dysplastic nevi has? Pebbly surface

49.    Potential precursor of malignant melanoma? Dysplastic nevus

50.    Nevus confused with melanoma? Blue nevus

51.    Melanoma of the eye, arise from melanocytes in? Iris, ciliary body, choroid and pigmented retinalepithelium

52.    Most common type of melanoma of the eye? Mixed pattern (Spindle cell and epitheloid)

53.    Most common site for Malignant melanoma inwomen? Lower extremity

54.    Most common site for Malignant melanoma inmen? Back

55.    Most important clinical sign of malignantmelanoma? Change in color in a pigmented lesion

56.    Melanoma specific antigen is? HMB 45

57.    Histological subtypes of melanoma with badprognosis are? Amelanotic& balloon cell melanoma

58.    Important prognostic factor in melanoma is? Vertical spread(Breslow’s staging)

59.    Coin like, waxy, flat plaques, tan-dark brown withgranular surface and “stuck on” appearance? Seborrheic keratosis

60.    Subacute dermatitis? Nummular dermatitis

61.    Deposition of Amyloid occurs in? Extracellular space

62.    The most common light chain found in ALprotein of amyloidosis? Lambda light chains(especially lamda VI)

63.    AL protein is derived from? Plasma cells (immunocytes)

64.    The amyloid associated protein (AA) is a? Non immunoglobulin protein synthesized by liver

65.    Most frequent associated condition with reactivesystemic amyloidosis (secondary amyloidosis)? Rheumatoid arthritis

66.    The type of amyloid protein in ageing associated(senile cardiac) amyloidosis is? Normal transthyretin

67.    Amyloidosis of aging involves? Heart, lungs, pancreas and spleen

68.    Clinical manifestations in amyloidosis are due toinvolvement of? Kidney, Heart and GIT

69.    ?2 microglobulin (structurally normal) is found inamyloidosis associated with? Dialysis

70.    The Beta-2 amyloid protein is found in? Alzheimer’s disease

71.    Most common tumor associated with reactivesystemic amyloidosis? Renal cell carcinoma and Hodgkin’s disease

72.    Most common cause of death in amyloidosis? Renal amyloidosis

73.    Most serious and most common form of organinvolvement in primary amyloidosis? Kidney

74.    Amyloid material can be confirmed by? Congo Red staining (apple green birefringenceunder polarizing microscope)

75.     In kidney amyloid is deposited? Primarily in glomeruli

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