One Liner (19/05/2019)
Published on May 19, 2019, 10 a.m.

1 Northern blot Is done for ?  RNA

2 Melatonin is synthesized from ? Tryptophan

3. Precursor of tyrosine ? Phenylalanine

4. Rotheras test is done for ? Ketone bodies

A Wernicke-Korsakoff syndrome is associated with deficiency of ? Vitamin B1 (Thiamine)

6. Methyl malonic aciduria is seen in deficiency of ? Vitamin B12

7. RBC Transketolase is associated with ? Vitamin B1 {Thiamine)

o. Alpha 2, Gamma 2 is which hemoglobin ? HbF

9. Cancer cells derive energy by ? Glycolysis

10. Agent added to blood for estimating blood glucose (added to prevent glycolysis) ? Sodium fluoride

11 . Fluoride inhibits which enzyme ? Enolase

12. First substrate of cikic acid cycle is ? Pyruvate, which forms acetyl CoA, which starts Krebs cycle

13. In TCA, substrate level phosphorylation occurs in reaction catalyzed by enzyme ? Succinyl CoA thiokinase

14. HMG CoA synthase is rate limiting enzyme for ? Ketone body synthesis

15. Muscle cannot make use of glycogen as they lack ? GIucose -6 - P hosphatase

16. HMP shunt is important as it produces ? NADPH

17. Number of ATP produced in HMP shunt ? Zero

'18. Enzyme deficient in von Gierke's disease ? GIucose-6-P hosphafase

19. ln galactosemia, cataract occurs because of the accumulation of ? Dulcitol/Galactitol

20. Most essential fatty acid is ? Linoleic acid

21 . Rate limiting enzyme in cholesterol synthesis ? HMG CoA reductase

22. Beta oxidation of fatty acids produces ? Propionyl CoA

23.  Ketone bodies are formed in ? Liver

24. lmportant feature of ketosis in starvation ? Ketosis without glycosuria

25. Most atherogenic lipoprotein ? LDL

t6. Western blotting is done for ? Proteins

27. Final product of purine metabolism ? Uric acid

zo_ Building block for fatty acid biosynthesis ? Acetyl CoA

29. Defi ciency of sphingomyelinase causes ? Niemann-Pick disease

30. Good cholesierol is ? HDL

Jt. Element required for phosphofructokinase ? Magnesium

JZ. Ammonia is detoxified in brain to ? Glutamine

Thyroxine is synihesized from ? Tyrosine

34. Niacin is synthesized from ? Tryptophan

35. Source of nitrogen in urea cycle ? Ammonia and aspartic acid

36. Limiiing amino acids in wheat ? Lysine and Threonine

aa Tyrosine becomes essential in which condition ? Phenylketonuria

ao Mousy odour of urine is present in?  Phenyloketonuria

3S. Most direct precursor of taurine is ? Cysteine

40. Precursor of adrenaline and noradrenaline ? Tyrosine

41 . Ochronosis is seen in ? Alkaptonuria

42. Cycle occurring both in cytosol as well as mitochondria ? Urea cycle

4J. Andersen disease is due to deficiency of which enzyme ? Branching enzyme

44 End product of anaerobic Glycolysis ?  Lactate

45. Rate limiting step in ketone bodies synthesis ? HMG CoA synthase

46 Production of uric acid is by ? Purine metabolism

47. Base present in RNA, but absent in DNA ? Uracil

48 Malonate inhibits ? Succinate dehydrogenase enzyme

45. DNA double helix is held by ? Hydrogen bonds

50 Free fatty acids are transported bound to ? Albumin

1. Pasteurization (Holder/Flash Method)? Milk

2. Inspissation? E.g. Serum / Egg media Loeffler’s serum slope, L-J medium.

3. MOIST HEAT > C Autoclave? Most culture media, rubber material, gloves linen etc.100

4. FILTRATION? Sera, sugars, Antibiotic solutions. Toxins, Hydatid fluid, purification of water.

5. Ionising radiations E.g. Gamma Rays,  X-rays, cosmic rays? Sterilization of disposable items like swabs, plastic syringes, culture plates, cannulae and catheters etc.

6. Non-ionising   radiations Infrared and ultraviolet radiations? Rapid mass sterilization of syringes and catheters.

7. Thermocouple? Brown’s tubes, Autoclave tapes

8. Chemical indicator? Brown’s tubes, Autoclave tapes

9. Autoclave Hot air oven? Geobacillus stearothermophilus

10. Ethylene oxide? Nontoxigenic C.tetani

11. Ethylene oxide?  Spores B. subtilis

12. Common indicator of faecal pollution of water? Escherichia coli, Streptococcus fecalis and Clostridium perfringens.

13. BACTERIOLOGICAL EXAMINATION OF MILK Viable count? Methylene blue

14. BACTERIOLOGICAL EXAMINATION OF MILK Coliform count? Phosphatase test

15. BACTERIOLOGICAL EXAMINATION OF MILK Chemical tests? Turbidity test

16. Obligate aerobe? Eg. Pseudomonas.

17. Microaerophilic organism? Eg. Campylobacter

18. Obligate anaerobe? Eg. Clostridium tetani

19. Capnophilic bacteria? Require higher level of CO2 Eg. Brucella

20 RCM – Saccharolyticorganisms– Proteolytic? 1) Turn meat pink,2) Turn meat black

21. Swarming prevented byadding? 6% agar, 1:500chloral hydrate, Naazide,alcohol,boric acid.

22. Most intestinal strains? Do not possess K antigens

23. Most common type of ‘K’ Ag? L Type

24. Toxin production controlledby? Plasmids

25. KLEBSIELLA AND PROTEUS Important features of Klebsiella? Nonmotile, capsulated

26. Non lactose fermenting klebsiella? K. ozaenae K. rhinoscleromatis

27. Important features of Proteus? Pleomorphism

28. Reference centre for phage typing of Staphylococci in India? Maulana Azad Medical College, New Delhi.

 lactamase production,  controlled by transducible plasmid29. Penicillin resistance in staphylococcus is due to?

30. Vancomycin intermediate S. aureus? Lack of or inaccessibility of certain penicillin – binding proteins due to mecA gene – intrinsic chromosomal mechanism

31. Staphylococcus saprophyticus differs from Staphylococcus epidermidis by resistance to? Novobiocin

32. Nonmotile strains used in Weil Felix test? 0 X 2, 0 X 19 and 0 X K

33. Confirmatory test for Proteus? Production of phenyl pyruvic acid

34. Vibrio cholerae was discovered by? Koch

35. Infundibuliform or Napiform Liquifaction in gelatin stab culture is found in? Vibrio cholera

36. Classical cholera Vibrio is? Voges Proskauer (V-P) negative and non-haemolytic.

37. Cholera toxin is an enterotoxin? It acts through cAMP pathway

38. Selective media for Vibrio cholera? TCBS – thiosulphate, citrate, bile salts and sucrose

39. Cholera vaccine now usedcontains? 8000 millions / ml. of Vibrio cholera composed of equal  number of Ogawa and Inaba serotypes

40. Red leg disease in frog is caused by? Aeromonas  hydrophila

41. Optimum pH for growth of Vibrio cholera? 8.2

42. Transport media for cholera? (i) VR medium (ii) Alkaline peptone water

43. Which condition predisposes to cholera? Achlorhydria

44. Cholera Vibrio possessboth? Exotoxin & Endotoxin

45. Special high salt blood selective agar used in halophilic Vibrios? Wagatsuma agar

46. Sanarelli-schwartzman reaction is observed in? Experimental cholera

47. CAMPYLOBACTER Selective medium for campylobacter? Skirrow’s medium Butzler’s medium

48. CAMPYLOBACTER Transport medium? Cary Blair medium

49. CAMPYLOBACTER Thermophilic campylobacter? C. jejuni, C. coli, C. lardi

50. Staphylococcal food poisoning begins? 2-6 hour after ingestion. Preformed, heat stable toxin

51. Pathogenic staphylococci are? Coagulase positive & mannitol fermenting

52. QUICK FACTS Bence Jones Protein abnormal antibody? Coagulate at 50

53. QUICK FACTS Bence Jones Protein abnormal antibody? Redissolve at 70

54. QUICK FACTS Cold antibodies? IgM, complete

55. QUICK FACTS Rheumatoid factor? IgM against IgG (Fc)

56. ADENOVIRUSESPharyngoconjunctivalfever is caused byadenovirus type? 3, 7 & 17

57. ADENOVIRUSESAcute haemorrhagiccystitis is caused byadenovirus types? 11 and 21

58 ADENOVIRUSESDiarrhoea in children iscaused by? Adenovirus types -40, 41

59. Complement? Coined by Ehrlich. Augments (complements) action of antibody. Constitutes 10-15% of total serum globulins.

60. Pathways of activation? Classical

61. Cell wall of fungus have? Chitin & mannose

62. Cytoplasmic membrane of fungi have? Sterols

63. CYTOMEGALOVIRUS/HHV-5 Cytomegalic inclusion diseases?Microcephaly

64.CYTOMEGALOVIRUS/HHV-5 Cytomegalic inclusion diseases?Chorioretinitis

64.CYTOMEGALOVIRUS/HHV-5 Cytomegalic inclusion diseases?Cerebralcalcification

66.CYTOMEGALOVIRUS/HHV-5 Cell line for culture? Human fibroblastcell line

67.ADENOVIRUSESAdenovirus capsid has252 capsomeres? 240 are hexons and12 are pentons

68.ADENOVIRUSESEpidemickeratoconjunctivitis iscaused by? Type 8, 19, 37Adenovirusassociated withcontaminatedophthalmicsolutions and rollertowels

69.ArbovirusesVector of KFD? Haemaphysalis

70.ArbovirusesReservoir host in KFD? Spinigera

71.ArbovirusesAmplifier host in KFD? Small forest

72.ArbovirusesReservoir host in JE? Mammals

73.ArbovirusesAmplifier host in JE? MonkeyHeronsPig

74.Largest viruses belong to? Pox group (300 nm)

75.Smallest virus is? Parvovirus (appro-ximately 20 nm)

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