1. Which anti cancer drug is eliminated by lung:

 

A. Cyclophosphamide

 

B. 5-FU

 

C. Enalapril

 

D. Cisplatin

 

2. Which does not act 2^nd messenger?

 

A. cAMP

 

B. Guanyl cyclase

 

C. Diacyl glycerol

 

D. Inositol triphosphate

 

3. Intrinsic activity is present in:

 

A.  Labetalol                

 

B.  Propranolol

 

C.  Sotalol                   

 

D.  Atenolol

 

4. Which of the following is not a part of phase I reaction?

 

A.  Oxidation                

 

B. Reduction

 

C.  Conjugation                        

 

D.  Hydrolyses

 

5.  Infliximab contraindicated in:

 

• Seronegative osteoarthritis
• Psoriatic arthritis
• SLE
• Reiter’s syndrome

6. Adjustment of dose of drug not required in cirrhosis of liver:

 

• Lorazepam
• Theophylline
• Metronidazole
• Diazepam

 

7. Which of the following drug is not used in Detrusor instability:

 

A.  Flavoxate               

 

B. Solifenacin

 

C. Tolterodine              

 

D. Tropspium   

 

8.  Loading dose depends on

 

A. Half life

 

B. Plasma volume

 

C. Volume of distribution

 

D. Rate of clearance

 

9. Buprenorphine is

 

• Partial opioid agonist
• Pure opioid agonist
• Pure opioid antagonist
• Opioid with strong analgesic property

 

 

10.  True about carbamazepine?

• Can cause megaloblastic anemia
• Levels are decreased by erythromycin
• Can be used in treatment of Fabry disease
• Hyponatremia is common with its longterm use

 

 

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1. The Answer is C

 

 

	Inactive	Active
Colloid	Abundant	Scalloped/ reabsorption Lacunae
Follicle	Large	Small
Cells	Flat	Columnar

2. The Answer is D

 

 

Synthesis of thyroid hormones

Occurs in colloid

Oxidation & Binding by®Thyroid peroxidase

Coupling reaction :

DIT + DIT                             T₄

MIT + DIT                            T₃

DIT + MIT                            RT₃

 

3. The Answer is D

 

 

Transthyretin        =  TBPA

Highest capacity to bind T₄  : Albumin

Highest affinity to bind T₄    : TBG

 

4. The Answer is  B

 

 

Glomerulosa         :               15%

Fasciculata           :               50%

Reticularis             :               7%

Rest                        :               Medulla

• Zona glomerulosa
• Zona fasciulata
• Zona reticularis
• A, B and C
• B and C
  • ­es SBP, DBP, MAP,
  • Only slight ­     in PP

From the option given above, indicate the appropriate source(s) each of the for owing hormones

 

5. The Answer is A

 

 

Pro insulin breaks downs to form insulin and C-peptide

 

6. The Answer is D

Norepinephrine (NE)

Epinethrine (E)

•  ­  SBP,­­  PP
• ­Slight    in map
• ¯DBP

Heart Rate (HR)

NE – reflex bradycardia

E – Tachycardia

 

7. The Answer is D

Dopamine causes natriaresis by inhibiting Na⁺_K⁺ ATPase

 

8. The Answer is D

Exercise                 :               NE­             >>      E­

Asphyxia/Hypoxia:            NE­             >         E­          

Familiar Stress      :               NE­             >         E­

(Unfamiliar Stress:              E­                >         NE­  )

After

After hypophysectomy epinephrine synthesis decreases

NE                                          E

PNMT                    [PNMT is stimulated by glucocorticoids]

Adrenalectomy                           

• Free E in plasma becomes zero
• NE unchanged
  • Cortisol
  • Cortico sterione
  • Deoxy corticosterone

 

9. The Answer is B

 

 

C27                                        Cholesterol

C21                                        17 Hydroxy corticosteroids

                        Progesterone

                        Corticosteroids

C19                                        17- Ketosteroids

                        Androgens

C18                                        Estrogens

C17                                        CPPP ring

Adr. Cortex  secretes mainly C₂₁ , C₁₉

C₁₉          :               Androgenic activity

C_{21                :}                       Mineralocorticoid activity

                                &

                Glucocorticoid activity

                Glucocorticoids

Mineralocorticoids

1.   Aldosterone

Androgens

1. DHEA

2. Androsteine dione

                        (Cortisone : From cortisol, in liver. Does not come into circulation)

                        Corticosterone : Has mineralocorticoid Activity)

 

10. The answer is D

 

 

The NMDA receptor channel is a large channel permeable to Ca K and It is activated by glutamate but unlike other glutamate receptor channels, the NMDA channel is blocked by Mg in its resting state. Depolarization of the cell membrane to approximately — 40 mV removes the Mg²⁺ blockade. Therefore, the NMDA channel is only Opened when the cell is depolarized by other excitatory neurotransmitters The Ca entering the cell activates a number of intraocular enzymes, some of which may be involved in memory.